Abstract
Bioreducible disulfide linkage-employing drug conjugate has already been approved for drug delivery application, and also has shown immense potential in gene and siRNA transfection. This paper will focus on the recent developments in bioreducible polymeric systems for gene and siRNA delivery application, and will discuss the advantages and challenges associated with reducible polymeric carriers.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Biocompatible Materials / chemistry*
-
Cell Line, Tumor
-
Disulfides / chemistry
-
Gene Transfer Techniques*
-
Genetic Therapy / instrumentation
-
Genetic Therapy / methods
-
Genetic Vectors
-
Humans
-
Models, Biological
-
Oxidation-Reduction
-
Polymers / chemistry*
-
RNA, Small Interfering / metabolism*
-
Transfection
Substances
-
Biocompatible Materials
-
Disulfides
-
Polymers
-
RNA, Small Interfering