Abstract
Oncocytic tumours are characterised by hyperproliferation of mitochondria. We immunohistochemically analysed all enzymes of the oxidative phosphorylation system in 19 oncocytic thyroid tumours. A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrounding non-cancerous tissue.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenoma / enzymology
-
Adenoma / genetics
-
Adenoma / pathology
-
Adolescent
-
Adult
-
Aged
-
Aged, 80 and over
-
Carcinoma / enzymology
-
Carcinoma / genetics
-
Carcinoma / pathology
-
DNA, Mitochondrial / genetics
-
Electron Transport Complex I / deficiency*
-
Electron Transport Complex I / genetics
-
Female
-
Gene Expression Regulation, Enzymologic
-
Gene Expression Regulation, Neoplastic
-
Genome
-
Goiter / enzymology
-
Goiter / genetics
-
Goiter / pathology
-
Humans
-
Hyperthyroidism / enzymology
-
Hyperthyroidism / genetics
-
Hyperthyroidism / pathology
-
Immunohistochemistry
-
Male
-
Mitochondria / enzymology
-
Mitochondria / genetics
-
Mitochondria / pathology
-
Oxidative Phosphorylation
-
Thyroid Neoplasms / enzymology*
-
Thyroid Neoplasms / genetics*
-
Thyroid Neoplasms / pathology
Substances
-
DNA, Mitochondrial
-
Electron Transport Complex I