Renal cell carcinoma associated immunosuppressive therapy: a case report with Wegener's granulomatosis

Rheumatol Int. 2009 Nov;30(1):119-21. doi: 10.1007/s00296-009-0911-x.

Abstract

Development of uroepithelial tumors after cyclophosphamide and azathioprine therapy in Wegener's granulomatosis (WG) have been reported in the literature but renal cell carcinoma (RCC), rarely. RCC associated with WG has been previously reported in a few cases. Most of them have simultaneous diseases. Here, we report a case, which developed RCC 8 years after initiation of WG. Long-term immunosuppressive treatment is a risk factor for the development of malignancies; it should be suggested that RCC in our patient might be due to immunosuppressive therapy.

Publication types

  • Case Reports

MeSH terms

  • Azathioprine / administration & dosage
  • Azathioprine / adverse effects*
  • Carcinoma, Renal Cell / chemically induced*
  • Carcinoma, Renal Cell / pathology
  • Carcinoma, Renal Cell / surgery
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / adverse effects*
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Granulomatosis with Polyangiitis / drug therapy*
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / adverse effects*
  • Kidney Neoplasms / chemically induced*
  • Kidney Neoplasms / pathology
  • Kidney Neoplasms / surgery
  • Male
  • Middle Aged
  • Nephrectomy
  • Time Factors
  • Treatment Outcome

Substances

  • Immunosuppressive Agents
  • Cyclophosphamide
  • Azathioprine