Abstract
We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele, one ABCB1 1236 C allele and one UGT1A1*28 variant 7 repeat demonstrated a statistically significant association with Grade 3/4 toxicities in metastatic colorectal cancer patients.
Publication types
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Clinical Trial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
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Adult
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Aged
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Alleles
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Antineoplastic Agents, Phytogenic / adverse effects*
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Antineoplastic Agents, Phytogenic / pharmacokinetics
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Antineoplastic Agents, Phytogenic / therapeutic use
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Camptothecin / adverse effects
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Camptothecin / analogs & derivatives*
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Camptothecin / pharmacokinetics
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Camptothecin / therapeutic use
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Colorectal Neoplasms / drug therapy
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Female
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Glucuronosyltransferase / genetics
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Humans
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Irinotecan
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Liver-Specific Organic Anion Transporter 1
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Male
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Middle Aged
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Neoplasm Metastasis
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Organic Anion Transporters / genetics
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Polymorphism, Genetic*
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Prospective Studies
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Retrospective Studies
Substances
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ABCB1 protein, human
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ATP Binding Cassette Transporter, Subfamily B
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Antineoplastic Agents, Phytogenic
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Liver-Specific Organic Anion Transporter 1
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Organic Anion Transporters
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SLCO1B1 protein, human
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Irinotecan
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UGT1A1 enzyme
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Glucuronosyltransferase
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Camptothecin