Abstract
In the present paper, vascular calcifications due to chronic renal failure in rats are studied by X-ray microtomography (micro-CT). Although micro-CT is traditionally used as an imaging technique, a quantitative analysis of data obtained by in vivo and ex vivo micro-CT is described and discussed. By comparison with traditional destructive methods, such as histomorphometry and atomic absorption, the detection limits for calcium were determined in living rats and in extracted aortas. micro-CT proved to be an effective non-invasive imaging technique allowing non-destructive quantification of ectopic calcifications.
Publication types
-
Comparative Study
-
Evaluation Study
MeSH terms
-
Adenine
-
Animals
-
Aorta / metabolism
-
Aorta / pathology
-
Aortic Diseases / diagnostic imaging*
-
Aortic Diseases / etiology
-
Aortic Diseases / metabolism
-
Aortic Diseases / pathology
-
Aortography / methods*
-
Calcinosis / diagnostic imaging*
-
Calcinosis / etiology
-
Calcinosis / metabolism
-
Calcinosis / pathology
-
Calcium / metabolism*
-
Disease Models, Animal
-
Kidney Failure, Chronic / chemically induced
-
Kidney Failure, Chronic / complications*
-
Kidney Failure, Chronic / diagnostic imaging
-
Male
-
Predictive Value of Tests
-
Rats
-
Rats, Wistar
-
Reproducibility of Results
-
Spectrophotometry, Atomic
-
Staining and Labeling / methods
-
Time Factors
-
X-Ray Microtomography*