Abstract
In pro- and eukaryotic cells, RuvB-like protein 2 (RBL2) resolves Holliday junction recombination intermediates. Here, we identified RBL2 as a suppressor of influenza A virus replication. Human RBL2 appears to interfere with the oligomerization of the viral nucleoprotein, a critical step in the assembly of viral replication complexes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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ATPases Associated with Diverse Cellular Activities
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Carrier Proteins / metabolism*
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Cell Line
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DNA Helicases / metabolism*
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Gene Expression Regulation, Viral
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Gene Knockdown Techniques
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Humans
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Influenza A virus / enzymology*
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Influenza A virus / physiology
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Nucleocapsid Proteins
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Protein Multimerization
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RNA, Viral / metabolism
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RNA-Binding Proteins / metabolism*
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RNA-Dependent RNA Polymerase / metabolism*
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Viral Core Proteins / metabolism*
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Virus Replication
Substances
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Carrier Proteins
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NP protein, Influenza A virus
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Nucleocapsid Proteins
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RNA, Viral
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RNA-Binding Proteins
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Viral Core Proteins
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RNA-Dependent RNA Polymerase
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ATPases Associated with Diverse Cellular Activities
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DNA Helicases
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RUVBL2 protein, human