Wilms tumor, AML and medulloblastoma in a child with cancer prone syndrome of total premature chromatid separation and Fanconi anemia

Pediatr Blood Cancer. 2009 Aug;53(2):208-10. doi: 10.1002/pbc.21966.

Abstract

Wilms tumor (WT) is the most common primary renal tumor in childhood. The occurrence of WT in patients with growth retardation, mental retardation and central nervous system abnormalities in association with premature chromatid separation (PCS) and mosaic variegated aneuploidy has been previously described in only 10 patients. Here we report the very rare occurrence of WT with two other malignancies, acute myeloid leukemia and medulloblastoma in association with chromosomal instability. This is a novel presentation of Fanconi anemia with this cytogenetic abnormality.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cerebellar Neoplasms / complications*
  • Cerebellar Neoplasms / drug therapy
  • Cerebellar Neoplasms / pathology
  • Child, Preschool
  • DNA Repair-Deficiency Disorders / complications*
  • DNA Repair-Deficiency Disorders / pathology
  • Fanconi Anemia / complications*
  • Fanconi Anemia / pathology
  • Female
  • Humans
  • Infant
  • Leukemia, Myeloid, Acute / complications*
  • Leukemia, Myeloid, Acute / drug therapy
  • Leukemia, Myeloid, Acute / pathology
  • Medulloblastoma / complications*
  • Medulloblastoma / drug therapy
  • Medulloblastoma / pathology
  • Wilms Tumor / complications*
  • Wilms Tumor / drug therapy
  • Wilms Tumor / pathology