[ATP-sensitive potassium channel and its cardiovascular protection effects]

Beijing Da Xue Xue Bao Yi Xue Ban. 2009 Apr 18;41(2):245-8.
[Article in Chinese]

Abstract

ATP-sensitive potassium channel(K(ATP)) consists of a 4.4 complex of an inwardly rectifying Kir6.x pore plus a sulfonylurea receptor, which is an ATP-binding cassette transporter. K(ATP) has been indentified in a variety of tissues and recognized as an important drug target. It connects cell metabolism with cell electric activity. K(ATP) has been proposed to play protective roles during heart failure, arrhythmia, myocardial infarction, stress, myocardial ischemia and hypertension. In this review, a summary of K(ATP) is presented with molecular structure, localization, regulation, cardiovascular protective effect and its mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / chemistry
  • ATP-Binding Cassette Transporters / physiology
  • Cardiovascular Diseases / prevention & control*
  • KATP Channels / chemistry*
  • KATP Channels / physiology*
  • Potassium Channels, Inwardly Rectifying / chemistry
  • Potassium Channels, Inwardly Rectifying / physiology
  • Receptors, Drug / chemistry
  • Receptors, Drug / physiology
  • Sulfonylurea Receptors

Substances

  • ATP-Binding Cassette Transporters
  • KATP Channels
  • Potassium Channels, Inwardly Rectifying
  • Receptors, Drug
  • Sulfonylurea Receptors
  • uK-ATP-1 potassium channel