Abstract
The memory of somatic cell gene expression is reset in the germline in a process that is accompanied by dramatic changes in chromatin modifications. In this issue, Katz et al. (2009) show that the histone demethylase Lsd1/Spr-5 may participate in this resetting process in the worm, thereby preventing a decline in germ cell epigenetic stability and viability over ensuing generations.
MeSH terms
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Animals
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Caenorhabditis elegans / cytology
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Caenorhabditis elegans / embryology*
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Caenorhabditis elegans / metabolism
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Caenorhabditis elegans Proteins / genetics
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Caenorhabditis elegans Proteins / metabolism
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Epigenesis, Genetic*
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Germ Cells / cytology*
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Germ Cells / metabolism
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Histones / metabolism
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Oxidoreductases, N-Demethylating
Substances
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Caenorhabditis elegans Proteins
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Histones
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Oxidoreductases, N-Demethylating
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SPR-5 protein, C elegans