The way of combination diseases and syndrome is an important style to diagnose and treat disease in traditional Chinese medicine (TCM) clinical practice today. The thoughts of formulating prescription based on combination modern diseases and syndrome changed profoundly and many styles arose. Combination pathogenesis with pathology to formulate prescription compensated for the insufficiency of treatment based on symptom differentiation. Combination effects of traditional Chinese medicine herbs with pharmacology action reflects a return from pharmacologic action to effects of traditional chinese herbs; Fixed prescription is sublimation of treatment according to syndrome differentiation. Changing classic prescription is still a major mean to formulate prescription. Integrating traditional chinese medicinal herbs with western drugs enhanced effect and reduced the side effects. Effective extract compatibility is a result and develoment of modern research and traditional theory about TCM.