Objective: To study the protective effect of Sarcandra glabra extract (SGE) on immune system in restrained mice.
Method: The male C57BL/6 mice were randomly divided into normal control group, stress control group, 125, 500 mg x kg(-1) SGE group. The spleen lymphocyte suspensions of each group were prepared. The parameters of spleen T cells subsets, NK cell and NKT cell proportion and number was detected by Flow cytometry.
Result: SGE regulated the balance of T cell subsets, increased the percent of NK cells and NKT cell proportion and number in restrained mice.
Conclusion: SGE has immunologic protective effect in restrained mice probably via the amelioration of immune cells proportion and number.