Abstract
A biocompatible, multimodal, and theranostic functional iron oxide nanoparticle is synthesized using a novel water-based method and exerts excellent properties for targeted cancer therapy, and optical and magnetic resonance imaging. For the first time, a facile, modified solvent diffusion method is used for the co-encapsulation of both an anticancer drug and near-infrared dyes. The resulting folate-derivatized theranostics nanoparticles could allow for targeted optical/magnetic resonance imaging and targeted killing of folate-expressing cancer cells.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / pharmacology*
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Diffusion
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Drug Delivery Systems
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Ferric Compounds / chemistry*
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Fluorescent Dyes / pharmacology*
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Folic Acid / chemistry
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Humans
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Ligands
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Magnetic Resonance Imaging / methods*
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Magnetics
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Metal Nanoparticles / chemistry*
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Nanotechnology / methods*
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Neoplasms / drug therapy*
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Neoplasms / metabolism
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Optics and Photonics
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Solvents / chemistry
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Spectrophotometry, Infrared / methods
Substances
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Antineoplastic Agents
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Ferric Compounds
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Fluorescent Dyes
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Ligands
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Solvents
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ferric oxide
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Folic Acid