Renal cell carcinoma (Grawitz tumor) is an epithelial tumor able, to develop, in some cases, very late metastases. The most frequent localization are: lung, bones and liver. Pancreatic metastasis are rare and appear late, sometime even after 12 years from primary renal tumor. In this cases the differential diagnosis must be made with primary pancreatic tumors. We present a case report of pancreatic metastatic tumor developed 5 years after right nephrectomy for renal cell carcinoma. We decide to perform cephalic duodenopancreatectomy (Wipple type).