Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines

Osama M Ahmed; Mahmoud A Mohamed; Rasha R Ahmed; Sayed A Ahmed

doi:10.1016/j.ejmech.2009.03.042

Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines

Eur J Med Chem. 2009 Sep;44(9):3519-23. doi: 10.1016/j.ejmech.2009.03.042. Epub 2009 Apr 8.

Authors

Osama M Ahmed¹, Mahmoud A Mohamed, Rasha R Ahmed, Sayed A Ahmed

Affiliation

¹ Zoology Department, Physiology Division, Faculty of Science, Beni-Suef University, Salah Salim Street, P.O. 62514, Beni-Suef 62514, Egypt. [email protected]

PMID: 19398146
DOI: 10.1016/j.ejmech.2009.03.042

Abstract

Cyclocondensation of cyanoacetamide, cyanothioacetamide and 3-aminopyrazols with sodium salt of 3-hydroxy-1-(2-naphthyl)prop-2-en-1-one gives pyridin-2-one, pyridin-2(1H)-thione, and pyrazolo[1,5-a]pyrimidine derivatives. These derivatives showed potent anti-tumor cytotoxic activity in vitro using different human cancer cell lines.

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Survival / drug effects
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Pyrazoles / chemical synthesis*
Pyrazoles / chemistry
Pyrazoles / pharmacology*
Pyridines / chemical synthesis*
Pyridines / chemistry
Pyridines / pharmacology*
Pyrimidines / chemical synthesis*
Pyrimidines / chemistry
Pyrimidines / pharmacology*
Structure-Activity Relationship

Substances

Antineoplastic Agents
Pyrazoles
Pyridines
Pyrimidines
pyrazolo(1,5-a)pyrimidine