Abstract
Oxaliplatin is a unique platinum derivative with anti-tumor activity in a number of malignancies, with neurotoxicity being a frequent side effect. Neurotoxicity can manifest in an acute phase and a chronic phase. The acute phase usually presents as dysesthesias of the hands and feet, jaw tightness, and pharyngolaryngo-dysesthesia, triggered and exacerbated by physical contact with cold temperatures. Although various other symptoms have been reported in the literature, little details are available. We report here, in detail, a case of blepharoptosis which appeared after repeated oxaliplatin infusions, and the disappearance of which seemed to be dependent on the infusion rate.
MeSH terms
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Aged
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Antibiotics, Antineoplastic / administration & dosage
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Antimetabolites, Antineoplastic / administration & dosage
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Antineoplastic Agents / adverse effects*
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Antineoplastic Agents / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Blepharoptosis / chemically induced*
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Capecitabine
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Deoxycytidine / administration & dosage
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Deoxycytidine / analogs & derivatives
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Epirubicin / administration & dosage
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Female
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Fluorouracil / administration & dosage
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Fluorouracil / analogs & derivatives
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Humans
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Organoplatinum Compounds / adverse effects*
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Organoplatinum Compounds / therapeutic use
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Oxaliplatin
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Stomach Neoplasms / complications
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Stomach Neoplasms / drug therapy
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Vision Disorders / chemically induced
Substances
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Antibiotics, Antineoplastic
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Antimetabolites, Antineoplastic
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Antineoplastic Agents
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Organoplatinum Compounds
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Oxaliplatin
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Deoxycytidine
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Epirubicin
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Capecitabine
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Fluorouracil