Abstract
A new sesamin type furofuran lignan, (-)-sesamin-2,2'-diol (1), along with two known flavonoids (2 and 3) and three phenolic compounds (4-6) were isolated from the aerial parts of Isodon japonicus. The structures of these compounds were determined by analysis of spectroscopic data (1D-, 2D-NMR, HRMS and CD) and by comparison of the data with those of related metabolites.
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology
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Cell Line
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Chromatography, Liquid
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Circular Dichroism
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Isodon* / chemistry
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Lignans / chemistry*
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Lignans / isolation & purification
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Lignans / pharmacology
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Macrophages / metabolism
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Nitric Oxide / metabolism
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Plant Components, Aerial
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Spectrometry, Mass, Electrospray Ionization
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Tandem Mass Spectrometry
Substances
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Anti-Inflammatory Agents
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Lignans
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Lipopolysaccharides
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Nitric Oxide