Abstract
Cardiac RXFP1 was upregulated upon activation of the alpha(1)-adrenergic receptor (AR) through signal pathways involving protein kinase A and C and ERK. In contrast, beta(1)-AR activation downregulated expression of cardiac RXFP1 and it further counteracted the alpha(1)-AR-mediated RXFP1 upregulation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic alpha-Agonists / pharmacology*
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Adrenergic beta-Agonists / pharmacology*
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Animals
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Animals, Newborn
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Cells, Cultured
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Gene Expression Regulation / drug effects*
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Immunohistochemistry
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Mice
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Mice, Transgenic
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Myocytes, Cardiac / drug effects*
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Myocytes, Cardiac / metabolism*
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Rats
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Receptors, Adrenergic, alpha / genetics
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Receptors, Adrenergic, alpha / metabolism
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Receptors, Adrenergic, beta / genetics
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Receptors, Adrenergic, beta / metabolism
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Receptors, G-Protein-Coupled / genetics*
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Receptors, G-Protein-Coupled / metabolism*
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Receptors, Peptide / genetics*
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Receptors, Peptide / metabolism*
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Reverse Transcriptase Polymerase Chain Reaction
Substances
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Adrenergic alpha-Agonists
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Adrenergic beta-Agonists
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RXFP1 protein, mouse
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Receptors, Adrenergic, alpha
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Receptors, Adrenergic, beta
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Receptors, G-Protein-Coupled
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Receptors, Peptide
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Rxfp1 protein, rat