Life-threatening infection caused by daptomycin-resistant Corynebacterium jeikeium in a neutropenic patient

J Clin Microbiol. 2009 Jul;47(7):2328-31. doi: 10.1128/JCM.00457-09. Epub 2009 May 6.

Abstract

Daptomycin is a novel lipopeptide antibiotic agent approved for the treatment of gram-positive life-threatening infections. Here we report, for the first time, the isolation of a highly daptomycin-resistant strain of Corynebacterium jeikeium causing a life-threatening infection in a neutropenic patient undergoing cord blood transplantation for secondary acute myeloid leukemia.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Cord Blood Stem Cell Transplantation / adverse effects
  • Corynebacterium / drug effects*
  • Corynebacterium / isolation & purification*
  • Corynebacterium Infections / microbiology*
  • Daptomycin / pharmacology*
  • Humans
  • Leukemia, Myeloid, Acute / complications
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged

Substances

  • Anti-Bacterial Agents
  • Daptomycin