Marker constituents of the natural antioxidant Eucalyptus leaf extract for the evaluation of food additives

Biosci Biotechnol Biochem. 2009 May;73(5):1060-5. doi: 10.1271/bbb.80832. Epub 2009 May 7.

Abstract

In order to establish the marker constituents of the natural antioxidant food-additive Eucalyptus leaf extract, the UV-absorbing constituents of two eucalyptus leaf extracts registered as food additives (eucalyptus A and B) were investigated. Several major peaks on the reversed-phase HPLC chromatogram of eucalyptus A were characterized as gallic acid, ellagic acid, 3-O-beta-D-glucuronides of quercetin and kaempferol, and a hydrolyzable tannin dimer, oenothein B, by direct comparison with authentic specimens isolated from Eucalyptus globulus leaves. A new gallotannin was found in the E. globulus leaf extract, and its structure was found to be 1,2,3,6-tetra-O-galloyl-beta-D-galactose. Two major peaks on the HPLC chromatogram of eucalyptus B were identified as gallic acid and ellagic acid, indicative of degradation products from hydrolyzable tannins in the leaves. Considering the evaluation of antioxidant activity by radical scavenging ability, a standardization of eucalyptus leaf extract, including the antioxidative polyphenol, oenothein B, is proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products / chemistry*
  • Biomarkers / analysis
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Eucalyptus / chemistry*
  • Food Additives / chemistry*
  • Free Radical Scavengers / chemistry*
  • Plant Extracts / chemistry*
  • Plant Leaves / chemistry*

Substances

  • Biological Products
  • Biomarkers
  • Food Additives
  • Free Radical Scavengers
  • Plant Extracts