Abstract
A highly efficient (18)F-labeling synthon for universal protein labeling is reported. Diverse (18)F-labeled proteins of 66-144 kDa were prepared with [(18)F]SiFA-isothiocyanate synthesized by an isotopic (19)F for (18)F exchange at the silicon atom. Overall preparative radiochemical yields were 20-40 % after 40-50 min. No bone uptake of (18)F radioactivity was detected until 90 min post-injection of (18)F-SiFA-RSA; this demonstrates the metabolic stability of the [(18)F]SiFA moiety.
MeSH terms
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Animals
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Apoproteins / chemistry
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Cattle
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Fluorides / chemistry
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Immunoglobulin G / chemistry
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Isothiocyanates / chemistry*
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Isothiocyanates / pharmacokinetics
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Isotope Labeling
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Lysine / chemistry*
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Male
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Organosilicon Compounds / chemistry
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Proteins / chemistry*
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Radiopharmaceuticals / chemistry*
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Radiopharmaceuticals / pharmacokinetics
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Rats
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Rats, Sprague-Dawley
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Serum Albumin / chemistry
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Transferrin / chemistry
Substances
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Apoproteins
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Immunoglobulin G
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Isothiocyanates
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Organosilicon Compounds
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Proteins
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Radiopharmaceuticals
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Serum Albumin
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Transferrin
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apotransferrin
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Lysine
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Fluorides