Successful prophylaxis with valaciclovir for relapsing HSV-1 in a girl treated with infliximab for moderate Crohn's disease

Eur J Gastroenterol Hepatol. 2009 Sep;21(9):1095-6. doi: 10.1097/MEG.0b013e32831de271.

Abstract

Biological agents such as inhibitors of tumour necrosis factor alpha (TNF-alpha ) are associated with the development of opportunistic infections. Although there are no international recommendations for the management of opportunistic infections, their prevention is a key safety issue for patients with inflammatory bowel disease (IBD). We report that chemoprophylaxis with oral valaciclovir was effective in preventing Herpes simplex virus (HSV-1) reactivation in a girl treated with infliximab for Crohn's disease.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / analogs & derivatives*
  • Acyclovir / therapeutic use
  • Adult
  • Anti-Inflammatory Agents / therapeutic use*
  • Antibodies, Monoclonal / therapeutic use*
  • Crohn Disease / drug therapy*
  • Female
  • Herpesvirus 1, Human / drug effects*
  • Herpesvirus 1, Human / physiology
  • Humans
  • Infliximab
  • Opportunistic Infections / prevention & control*
  • Secondary Prevention
  • Valacyclovir
  • Valine / analogs & derivatives*
  • Valine / therapeutic use
  • Virus Activation / drug effects

Substances

  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal
  • Infliximab
  • Valine
  • Valacyclovir
  • Acyclovir