Fast attrition-enhanced deracemization of naproxen by a gradual in situ feed

Angew Chem Int Ed Engl. 2009;48(25):4581-3. doi: 10.1002/anie.200901386.

Abstract

Grind and cure: Using the nonsteroidal anti-inflammatory drug naproxen, a novel concept is demonstrated to dramatically enhance the rate of the recently discovered process of deracemization using abrasive grinding. The process relies on a gradual feed of the racemic target material by an in situ conversion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry*
  • Esterification
  • Isomerism
  • Naproxen / chemistry*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Naproxen