Abstract
Six new triterpenes (neoabieslactones A-F, 1-6) and 17 known compounds were isolated from the aerial parts of Abies chensiensis. The structures of the new triterpenes were proposed by 1D and 2D NMR spectroscopy. Compound 1 was confirmed structurally by X-ray crystallography. In a bioassay against LPS-induced NO production in RAW264.7 macrophages, three compounds, neoabieslactone E (5), (12R,13R)-8,12-epoxy-14-labden-13-ol (7), and manool (8), exhibited IC(50) values of 9.1, 1.9, and 9.6 microg/mL, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abies / chemistry*
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology*
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Crystallography, X-Ray
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Diterpenes / pharmacology
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Mice
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Molecular Conformation
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Molecular Structure
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Nitric Oxide / biosynthesis
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
Substances
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Anti-Inflammatory Agents
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Diterpenes
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Lipopolysaccharides
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Triterpenes
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Nitric Oxide
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manool