Lepirudin treatment in a girl with iliac vein thrombosis, severe pulmonary embolism and suspected heparin-induced thrombocytopenia (HIT) II

Klin Padiatr. 2009 May-Jun;221(3):174-5. doi: 10.1055/s-0029-1220702. Epub 2009 May 12.

Abstract

We report on a 15-year-old girl referred to us for dyspnea. Investigations revealed multiple pulmonary emboli originating from iliac vein thrombosis. As under heparin therapy, d-dimers rose again and the thrombus grew significantly in size while platelet count decreased by >30%. A diagnosis of heparin-induced thrombocytopenia (HIT) type II was suspected, heparin-treatment was stopped and lepirudin therapy was started successfully at a doses of 0.15 mg/kg bw/hr.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anticoagulants / adverse effects*
  • Anticoagulants / therapeutic use
  • Diagnosis, Differential
  • Dose-Response Relationship, Drug
  • Female
  • Fibrinolytic Agents / therapeutic use*
  • Heparin / adverse effects*
  • Heparin / therapeutic use
  • Hirudins
  • Humans
  • Iliac Vein*
  • Magnetic Resonance Angiography
  • Magnetic Resonance Imaging
  • Pulmonary Embolism / diagnosis
  • Pulmonary Embolism / drug therapy*
  • Recombinant Proteins / therapeutic use
  • Recurrence
  • Thrombocytopenia / chemically induced*
  • Thrombosis / diagnosis
  • Thrombosis / drug therapy*
  • Tomography, X-Ray Computed
  • Ultrasonography, Doppler
  • Vena Cava, Inferior

Substances

  • Anticoagulants
  • Fibrinolytic Agents
  • Hirudins
  • Recombinant Proteins
  • Heparin
  • lepirudin