Abstract
The disseminated cutaneous granulomatosis (DCG) are heterogeneous cutaneous diseases histologically characterized by a granulomatous infiltrate. The most frequent cutaneous granulomatosis is sarcoidosis, but many other causes can be found, because DCG are probably a skin granulomatous reaction to different stimuli: infectious, inflammatory, neoplastic, metabolic or chemical. The histopathological examination is useful for the diagnosis of DCG, but gives rarely an etiological diagnosis. In this article, we will propose a strategy for the etiological diagnosis of DCG, and propose therapeutic recommendations based on recent data from the literature.
MeSH terms
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Administration, Cutaneous
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Biopsy
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Dermatologic Agents / administration & dosage
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Drug Therapy, Combination
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Granuloma Annulare / diagnosis
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Granuloma Annulare / etiology
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Granuloma Annulare / pathology*
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Granuloma Annulare / therapy*
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Granulomatous Disease, Chronic / diagnosis
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Granulomatous Disease, Chronic / etiology
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Granulomatous Disease, Chronic / pathology*
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Granulomatous Disease, Chronic / therapy*
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Humans
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Immunosuppressive Agents / administration & dosage
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Phototherapy / methods
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Practice Guidelines as Topic
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Retinoids / administration & dosage
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Sarcoidosis / pathology
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Sarcoidosis / therapy
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Skin Diseases / pathology
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Skin Diseases / therapy
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Tacrolimus / administration & dosage
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Treatment Outcome
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
Substances
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Dermatologic Agents
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Immunosuppressive Agents
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Retinoids
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Tumor Necrosis Factor-alpha
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Tacrolimus