Presence of a multidrug-resistance mutation in an HIV-2 variant infecting a treatment-naive individual in Caio, Guinea Bissau

Clin Infect Dis. 2009 Jun 15;48(12):1790-3. doi: 10.1086/599107.

Abstract

We report the possible transmission of drug-resistant human immunodeficiency virus type 2. A 66-year-old woman from rural Guinea Bissau who had no obvious antiretroviral exposure was found to harbor a variant with the multidrug-resistance mutation Q151M. Finding this mutation among a drug-naive population presents an important public health issue that needs to be addressed for treatment to be effective.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Amino Acid Substitution / genetics
  • Anti-HIV Agents / therapeutic use
  • Drug Resistance, Multiple, Viral*
  • Female
  • Guinea-Bissau
  • HIV Infections / transmission
  • HIV Infections / virology*
  • HIV-2 / genetics*
  • HIV-2 / isolation & purification
  • Humans
  • Molecular Sequence Data
  • Mutation, Missense*
  • Sequence Analysis, DNA

Substances

  • Anti-HIV Agents

Associated data

  • GENBANK/AM408185
  • GENBANK/AM408186
  • GENBANK/AM408187
  • GENBANK/AM408188
  • GENBANK/AM408189
  • GENBANK/AM408190
  • GENBANK/AM408191
  • GENBANK/AM408192
  • GENBANK/AM408193
  • GENBANK/AM408194
  • GENBANK/AM408195
  • GENBANK/AM408196
  • GENBANK/AM408197
  • GENBANK/AM408198
  • GENBANK/AM408199
  • GENBANK/AM408200
  • GENBANK/AM408201
  • GENBANK/AM408202
  • GENBANK/AM408203
  • GENBANK/AM408204
  • GENBANK/AM408205
  • GENBANK/AM408206
  • GENBANK/AM408207
  • GENBANK/AM408208
  • GENBANK/FM877561