Abstract
Tetrachloromethane (2 g/kg, intragastric) produced a decrease in the activity of NAD- and NADH- dependent aldehyde dehydrogenases with high Km for aldehydes in rat liver. Panthenol and L-carnitine administered separately normalized the activity of aldehyde dehydrogenases, while a combination of the drugs did not produce any significant effect.
MeSH terms
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Aldehyde Oxidoreductases / metabolism
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Aldehydes / metabolism*
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Animals
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Carbon Tetrachloride Poisoning / metabolism*
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Carnitine / pharmacology*
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Chemical and Drug Induced Liver Injury / metabolism*
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Drug Interactions
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Liver / drug effects*
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Liver / enzymology
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Male
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Pantothenic Acid / analogs & derivatives*
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Pantothenic Acid / pharmacology
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Rats
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Rats, Wistar
Substances
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Aldehydes
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Pantothenic Acid
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dexpanthenol
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Aldehyde Oxidoreductases
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Carnitine