Abstract
Lipophilic fractions of stem extracts from Exocarpos latifolius, native to Papua New Guinea, showed significant activity against Mycobacterium tuberculosis H37Ra. Bioactivity-guided fractionation yielded exocarpic acid (E-octadeca-13-ene-9,11-diynoic-acid) as the major active component. Several new exocarpic acid analogs were also shown to be active. Exocarpic acid has previously been reported active against gram-positive, but not gram-negative bacteria. Work presented here demonstrates the selective activity of exocarpic acid against Mycobacterium tuberculosis H37Ra.
Georg Thieme Verlag KG Stuttgart, New York.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Chemical Fractionation
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Diynes / chemistry
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Diynes / isolation & purification
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Diynes / pharmacology*
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Fatty Acids, Unsaturated / chemistry
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Fatty Acids, Unsaturated / isolation & purification
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Fatty Acids, Unsaturated / pharmacology*
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Santalaceae / chemistry*
Substances
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Anti-Bacterial Agents
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Diynes
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Fatty Acids, Unsaturated
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Plant Extracts
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exocarpic acid