Abstract
The loading and containment of cargo within nanoparticles and their efficient delivery to cells represent a primary challenge in nanomedicine. We report lipid exchange between free and mesoporous silica nanoparticle-supported lipid bilayers as an effective means of containing cargo, controlling charge, and directing delivery to mammalian cells. The delivery of a membrane-impermeable dye (calcein) and a chemotherapeutic drug (doxorubicin) are demonstrated. Exchanged lipid bilayers minimized premature drug release, and an overall positive charge on the supported lipid bilayer effected enhanced delivery.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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CHO Cells
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Cricetinae
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Cricetulus
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Doxorubicin / administration & dosage
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Doxorubicin / chemistry
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Drug Delivery Systems / methods*
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Fatty Acids, Monounsaturated / chemistry
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Fluoresceins / administration & dosage
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Fluoresceins / chemistry
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Fluoresceins / pharmacokinetics
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Lipid Bilayers / chemistry*
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Liposomes / administration & dosage
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Liposomes / chemistry*
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Nanoparticles / administration & dosage
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Nanoparticles / chemistry*
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Quaternary Ammonium Compounds / chemistry
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Silicon Dioxide / chemistry
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Spectrometry, Fluorescence
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Static Electricity
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Surface Properties
Substances
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Fatty Acids, Monounsaturated
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Fluoresceins
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Lipid Bilayers
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Liposomes
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Quaternary Ammonium Compounds
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Silicon Dioxide
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Doxorubicin
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1,2-dioleoyloxy-3-(trimethylammonium)propane
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fluorexon