Functional mapping of the motor cortex of the rat using transdural electrical stimulation

Behav Brain Res. 2009 Aug 24;202(1):138-41. doi: 10.1016/j.bbr.2009.03.018. Epub 2009 Mar 24.

Abstract

Motor cortex stimulation oriented by functional cortical mapping is used mainly for treating otherwise intractable neurological disorders, however, its mechanism of action remains elusive. Herein, we present a new method for functional mapping of the rat motor cortex using non-invasive transdural electrical stimulation. This method allows a non-invasive mapping of the surface of the neocortex providing a differentiation of representative motor areas. This study may facilitate further investigation about the mechanisms mediating the effects of electrical stimulation, possibly benefiting patients who do not respond to this neuromodulation therapy.

MeSH terms

  • Animals
  • Brain Mapping / methods*
  • Electric Stimulation / methods*
  • Evoked Potentials, Motor
  • Male
  • Motor Activity / physiology
  • Motor Cortex / physiology*
  • Rats
  • Rats, Wistar