Efficacy of liposomal amphotericin B combined with gamma interferon or granulocyte-macrophage colony-stimulating factor for treatment of systemic zygomycosis in mice

M Mar Rodríguez; Enrique Calvo; Marçal Mariné; F Javier Pastor; Joan Fernandez-Ballart; Josep Guarro

doi:10.1128/AAC.00456-09

Efficacy of liposomal amphotericin B combined with gamma interferon or granulocyte-macrophage colony-stimulating factor for treatment of systemic zygomycosis in mice

Antimicrob Agents Chemother. 2009 Aug;53(8):3569-71. doi: 10.1128/AAC.00456-09. Epub 2009 May 18.

Authors

M Mar Rodríguez¹, Enrique Calvo, Marçal Mariné, F Javier Pastor, Joan Fernandez-Ballart, Josep Guarro

Affiliation

¹ Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain.

Abstract

Granulocyte-macrophage colony-stimulating factor enhanced the efficacy of liposomal amphotericin B (LAMB) in a murine model of disseminated infection by Rhizopus oryzae, significantly prolonging survival and reducing tissue burden. The use of gamma interferon (IFN-gamma) alone was ineffective, and IFN-gamma combined with LAMB did not improve the results obtained with LAMB alone.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amphotericin B / therapeutic use*
Animals
Antifungal Agents / therapeutic use*
Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use*
Interferon-gamma / therapeutic use*
Male
Mice
Rhizopus / physiology
Zygomycosis / drug therapy*
Zygomycosis / microbiology

Substances

Antifungal Agents
liposomal amphotericin B
Amphotericin B
Interferon-gamma
Granulocyte-Macrophage Colony-Stimulating Factor