Abstract
Cytochrome c is a pivotal protein that resides in mitochondria as component of mitochondria respiration and apoptosis initiator. Using murine cells lacking cytochrome c, we showed here that cytochrome c-deficient cells had attenuated reactive oxygen species/nitric oxide and micronuclei induction to radiation-induced bystander signals, indicating cytochrome c is essential for the bystander effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis
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Bystander Effect / radiation effects*
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Cell Culture Techniques
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Coculture Techniques
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Cytochromes c / metabolism*
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Gamma Rays
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Membrane Potential, Mitochondrial
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Mice
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Mice, Knockout
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Micronucleus Tests
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Mitochondria / enzymology*
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Mitochondria / pathology
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Mitochondria / radiation effects*
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Nitric Oxide / metabolism
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Reactive Oxygen Species / metabolism
Substances
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Reactive Oxygen Species
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Nitric Oxide
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Cytochromes c