Pharmacological optimization of tissue perfusion

Br J Anaesth. 2009 Jul;103(1):82-8. doi: 10.1093/bja/aep135. Epub 2009 May 21.

Abstract

After fluid resuscitation, vasoactive drug treatment represents the major cornerstone for correcting any major impairment of the circulation. However, debate still rages as to the choice of agent, dose, timing, targets, and monitoring modalities that should optimally be used to benefit the patient yet, at the same time, minimize harm. This review highlights these areas and some new pharmacological agents that broaden our therapeutic options.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood Pressure / drug effects
  • Cardiac Output / drug effects
  • Cardiotonic Agents / adverse effects
  • Cardiotonic Agents / pharmacology*
  • Cardiovascular System / drug effects*
  • Humans
  • Monitoring, Physiologic / methods
  • Oxygen Consumption / drug effects
  • Vasoconstrictor Agents / adverse effects
  • Vasoconstrictor Agents / pharmacology*

Substances

  • Cardiotonic Agents
  • Vasoconstrictor Agents