Abstract
The discovery and optimization of a series of potent PPARdelta full agonists with partial agonistic activity against PPARgamma is described.
MeSH terms
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Animals
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Computer Simulation
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Crystallography, X-Ray
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PPAR delta / agonists*
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PPAR delta / metabolism
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PPAR gamma / agonists*
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PPAR gamma / metabolism
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Rats
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Rats, Sprague-Dawley
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Thiazoles / chemical synthesis
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Thiazoles / chemistry*
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Thiazoles / pharmacology
Substances
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PPAR delta
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PPAR gamma
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Thiazoles