Abstract
When first reported in 1995, the mammalian Ste20-like kinases (Mst) 1 and 2 were so named both for their similarity to the yeast kinase Ste20 and for the fact that their function was, to us, a deep mystery. While much remains to be explained about the regulation and role of these kinases, the veil has been at least partly raised on the Msts, revealing unexpected modes of activation and function. Work in model organisms suggests a central growth-suppressive role for Mst orthologs, with intriguing possible links to other established tumor suppressors. This minireview underlines our current understanding of how Mst1 and Mst2 are regulated, and how activation of these proteins influences cell survival and proliferation.
MeSH terms
-
Animals
-
Apoptosis / physiology
-
Drosophila Proteins / genetics
-
Drosophila Proteins / metabolism
-
Hepatocyte Growth Factor / genetics
-
Hepatocyte Growth Factor / metabolism*
-
Humans
-
Intracellular Signaling Peptides and Proteins / genetics
-
Intracellular Signaling Peptides and Proteins / metabolism*
-
MAP Kinase Kinase Kinases
-
Protein Serine-Threonine Kinases / genetics
-
Protein Serine-Threonine Kinases / metabolism*
-
Proto-Oncogene Proteins / genetics
-
Proto-Oncogene Proteins / metabolism*
-
Saccharomyces cerevisiae Proteins / genetics
-
Saccharomyces cerevisiae Proteins / metabolism*
-
Serine-Threonine Kinase 3
-
Signal Transduction / physiology
Substances
-
Drosophila Proteins
-
Intracellular Signaling Peptides and Proteins
-
Proto-Oncogene Proteins
-
Saccharomyces cerevisiae Proteins
-
macrophage stimulating protein
-
Hepatocyte Growth Factor
-
Protein Serine-Threonine Kinases
-
STK3 protein, human
-
Serine-Threonine Kinase 3
-
hpo protein, Drosophila
-
MAP Kinase Kinase Kinases
-
STE20 protein, S cerevisiae