Abstract
Adnexal tumors with follicular differentiation in the breast parenchyma are rarely encountered. The authors present a unique case arising in a 64-year-old woman, in whom they observed composite differentiation toward follicular germinative cells of the hair follicle with focal areas of outer root sheath differentiation and pilar-type keratinization. The histogenesis of this tumor is analyzed in light of the peculiar pathological, immunohistochemical, and molecular genetic findings.
MeSH terms
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Biomarkers, Tumor / metabolism
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Breast Neoplasms / genetics
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology*
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Breast Neoplasms / surgery
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Cell Transformation, Neoplastic
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Female
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Hair Diseases / genetics
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Hair Diseases / metabolism
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Hair Diseases / pathology
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Hair Diseases / surgery
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Hair Follicle / pathology*
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Humans
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Middle Aged
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Mutation, Missense
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Neoplasms, Adnexal and Skin Appendage / genetics
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Neoplasms, Adnexal and Skin Appendage / metabolism
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Neoplasms, Adnexal and Skin Appendage / pathology*
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Neoplasms, Adnexal and Skin Appendage / surgery
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beta Catenin / genetics
Substances
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Biomarkers, Tumor
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CTNNB1 protein, human
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beta Catenin