Cytomegalovirus-associated protein-losing enteropathy resulting from lymphangiectasia in an immunocompetent child

Takayuki Hoshina; Koichi Kusuhara; Mitsumasa Saito; Takuya Hara; Shuji Mtsuura; Takashi Yano; Tomonobu Aoki; Toshiro Hara

Cytomegalovirus-associated protein-losing enteropathy resulting from lymphangiectasia in an immunocompetent child

Jpn J Infect Dis. 2009 May;62(3):236-8.

Authors

Takayuki Hoshina¹, Koichi Kusuhara, Mitsumasa Saito, Takuya Hara, Shuji Mtsuura, Takashi Yano, Tomonobu Aoki, Toshiro Hara

Affiliation

¹ Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. [email protected]

PMID: 19468191

Abstract

An immunocompetent 8-year-old boy with cytomegalovirus (CMV)-associated transient protein-losing enteropathy (PLE) is described. Colonoscopic examination revealed lymphoid hyperplasia of the terminal ileum. Histological examination of the biopsied specimens showed marked dilation of the lymphatic vessels. Primary CMV infection was demonstrated by serological test and polymerase chain reaction. The child had complete resolution of the disease without antiviral treatment. The present case suggests the etiologic role of CMV infection in PLE resulting from intestinal lymphangiectasia in childhood.

Publication types

Case Reports

MeSH terms

Antibodies, Viral / blood
Child
Cytomegalovirus / genetics
Cytomegalovirus / isolation & purification*
Cytomegalovirus Infections / complications
Cytomegalovirus Infections / diagnosis*
Cytomegalovirus Infections / virology
DNA, Viral / blood
Edema
Humans
Ileum / pathology
Ileum / virology
Immunocompetence
Intestinal Mucosa / pathology
Intestinal Mucosa / virology
Lymphangiectasis, Intestinal / complications
Lymphangiectasis, Intestinal / diagnosis*
Male
Polymerase Chain Reaction
Protein-Losing Enteropathies / diagnosis*
Protein-Losing Enteropathies / etiology
Protein-Losing Enteropathies / virology

Substances

Antibodies, Viral
DNA, Viral