Abstract
During the mass measles/rubella vaccination campaign in 2003 in Iran, many pregnant women were vaccinated mistakenly or became pregnant within 1 month of vaccination. To distinguish pregnant women who were affected by rubella vaccine as primary infection from those who had rubella reinfection from the vaccine, serum samples were collected 1-3 months after the campaign from 812 pregnant women. IgG avidity assay showed that 0.3% of the women had no rubella-specific IgG response; 14.4% had low-avidity anti-rubella IgG and were therefore not immune to rubella before vaccination; 85.3% had high-avidity anti-rubella IgG and were regarded as cases of reinfection.
MeSH terms
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Adolescent
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Adult
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Antibodies, Viral / blood
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Antibodies, Viral / immunology*
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Antibody Affinity / immunology
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Chi-Square Distribution
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Female
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Humans
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Immunoenzyme Techniques / methods*
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Immunoenzyme Techniques / standards
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Immunoglobulin G / blood
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Immunoglobulin G / immunology*
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Iran / epidemiology
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Mass Vaccination / adverse effects
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Mass Vaccination / methods
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Medical Errors / statistics & numerical data
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Predictive Value of Tests
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Pregnancy
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Pregnancy Complications, Infectious / blood
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Pregnancy Complications, Infectious / epidemiology*
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Pregnancy Complications, Infectious / immunology
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Pregnancy Complications, Infectious / virology
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Rubella / blood
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Rubella / epidemiology*
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Rubella / immunology
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Rubella / virology
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Rubella Vaccine / adverse effects*
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Rubella Vaccine / immunology
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Rubella virus / immunology*
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Seroepidemiologic Studies
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Statistics, Nonparametric
Substances
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Antibodies, Viral
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Immunoglobulin G
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Rubella Vaccine