Abstract
Examination of the acetone extract of the aerial parts of Hypericum ellipticum afforded a new acetylated benzophenone glucoside (3'-O-beta-D-3",4",6"-triacetylglucopyranosyl-2,4,5',6-tetrahydroxybenzophenone) together with catechin and epicatechin. The structure of the benzophenone glucoside was determined by 2D NMR spectroscopic data. The compound inhibited the proliferation of CNS tumor cell line (SF-268) and lipid peroxidation in in vitro assays.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzophenones / chemistry*
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Benzophenones / isolation & purification
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Benzophenones / pharmacology
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Catechin / chemistry
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Catechin / isolation & purification
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Catechin / pharmacology
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Cell Line, Tumor
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Cytostatic Agents / chemistry*
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Cytostatic Agents / isolation & purification
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Cytostatic Agents / pharmacology
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Glucosides / chemistry*
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Humans
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Hypericum / chemistry*
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Lipid Peroxidation / drug effects
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Nuclear Magnetic Resonance, Biomolecular
Substances
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3'-O-3'',4'',6''-triacetylglucopyranosyl-2,4,5',6-tetrahydroxybenzophenone
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Benzophenones
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Cytostatic Agents
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Glucosides
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Catechin