Biofilm formation by Candida species on silicone surfaces and latex pacifier nipples: an in vitro study

J Clin Pediatr Dent. 2009 Spring;33(3):235-40. doi: 10.17796/jcpd.33.3.7572960tn46837k4.

Abstract

The present study assessed the growth and development of biofilm formation by isolates of C. albicans, C. glabrata and C. parapsilosis on silicone and latex pacifier nipples. The silicone and latex surfaces were evaluated by scanning electronic microscopy (SEM). The plastic component of the nipple also seems to be an important factor regarding the biofilm formation by Candida spp. The biofilm growth was measured using the MTT reduction reaction. C. albicans was found to have a slightly greater capacity of forming biofilm compared to the other Candida species. Analysis of the pattern of biofilm development by C. albicans, C. glabrata and C. parapsilosis on latex and silicon pacifier shields showed an increased biofilm formation regarding the latter substrate. Silicone was shown to be more resistant to fungal colonization, particularly in the case of C. parapsilosis, despite the lack of any statistically significant differences (P > 0.05). In addition, silicone has a smoother surface compared to latex, whose surface was found to be rugose and irregular.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biofilms / growth & development*
  • Candida / physiology*
  • Cell Adhesion
  • Fomites / microbiology*
  • Humans
  • Infant
  • Latex
  • Microscopy, Electron, Scanning
  • Pacifiers / microbiology*
  • Silicones
  • Surface Properties
  • Tetrazolium Salts / metabolism
  • Thiazoles / metabolism

Substances

  • Latex
  • Silicones
  • Tetrazolium Salts
  • Thiazoles
  • thiazolyl blue