Fractures of the medial orbital wall can be isolated or associated with other orbital defects arising from maxillofacial fractures. However, a medial orbital wall defect results in a relative increase of the orbital volume. The decision regarding surgical intervention in the management of medial orbital wall fractures is influenced by a variety of factors, including the presence and severity of restricted ocular motility, the degree of enophthalmos, the estimated fracture size, and the clinical judgment of the surgeon; however, untreated medial orbital wall fractures can result in secondary enophthalmos. The aim of this study was to describe our experience with deantigenated swine bone cortex for the reconstruction of the fractured medial orbital wall.