Successful treatment with rituximab in an elderly patient with acquired factor VIII inhibitor

Geriatr Gerontol Int. 2009 Jun;9(2):197-9. doi: 10.1111/j.1447-0594.2008.00491.x.

Abstract

We report here on an elderly patient, aged 88 years, who developed acquired hemophilia, with a high titer of factor VIII inhibitors and severe hemorrhage, in the absence of a detectable cause. Marked and prolonged efficacy was observed after rituximab.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Monoclonal, Murine-Derived
  • Coagulants / immunology
  • Coagulants / therapeutic use
  • Factor VIII / immunology
  • Factor VIII / therapeutic use
  • Female
  • Hemophilia A / drug therapy*
  • Hemophilia A / immunology
  • Humans
  • Immunologic Factors / therapeutic use*
  • Immunosuppressive Agents / therapeutic use*
  • Rituximab
  • Treatment Outcome

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Coagulants
  • Immunologic Factors
  • Immunosuppressive Agents
  • Rituximab
  • Factor VIII