The CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 diabetes mellitus in the Portuguese population

M C Lemos; E Coutinho; L Gomes; M Bastos; A Fagulha; L Barros; F Carrilho; E Geraldes; F J Regateiro; M Carvalheiro

doi:10.1111/j.1744-313X.2009.00844.x

The CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 diabetes mellitus in the Portuguese population

Int J Immunogenet. 2009 Jun;36(3):193-5. doi: 10.1111/j.1744-313X.2009.00844.x.

Authors

M C Lemos¹, E Coutinho, L Gomes, M Bastos, A Fagulha, L Barros, F Carrilho, E Geraldes, F J Regateiro, M Carvalheiro

Affiliation

¹ Health Sciences Research Centre (CICS), Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal. [email protected]

PMID: 19490216
DOI: 10.1111/j.1744-313X.2009.00844.x

Abstract

CTLA4 genetic polymorphisms have been associated with type 1 diabetes. We genotyped 207 patients and 249 controls for the most frequently investigated polymorphism of the CTLA4 gene (+49A/G (rs231775)). No significant differences were observed, suggesting that this polymorphism is not strongly associated with type 1 diabetes in the Portuguese population.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Antigens, CD / genetics*
CTLA-4 Antigen
Case-Control Studies
Diabetes Mellitus, Type 1 / epidemiology
Diabetes Mellitus, Type 1 / genetics*
Female
Gene Frequency / genetics*
Genetic Predisposition to Disease
Genotype
Humans
Male
Polymorphism, Single Nucleotide
Portugal / epidemiology
Retrospective Studies
Young Adult

Substances

Antigens, CD
CTLA-4 Antigen
CTLA4 protein, human