Single-DNA molecule nanomotor regulated by photons

Nano Lett. 2009 Jul;9(7):2690-6. doi: 10.1021/nl9011694.

Abstract

We report the design of a single-molecule nanomotor driven by photons. The nanomotor is a DNA hairpin-structured molecule incorporated with azobenzene moieties to facilitate reversible photocontrollable switching. Upon repeated UV-vis irradiation, this nanomotor displayed 40-50% open-close conversion efficiency. This type of nanomotor displays well-regulated responses and can be operated under mild conditions with no output of waste. In contrast to multiple-component DNA nanomachines, the intramolecular interaction in this single-molecule system offers unique concentration-independent motor functionality. Moreover, the hairpin structure of the motor backbone can significantly improve the efficiency of light-to-movement energy conversion. These results suggest that azobenzene-incorporated, hairpin-structured single-molecule DNA nanomotors have promising potential for applications which require highly efficient light-driven molecular motors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Azo Compounds / chemistry
  • Base Sequence
  • DNA / chemistry*
  • Molecular Conformation
  • Molecular Sequence Data
  • Molecular Structure
  • Motion*
  • Nanotechnology*
  • Photons*
  • Spectrometry, Fluorescence

Substances

  • Azo Compounds
  • DNA
  • azobenzene