Abstract
A new dimeric phenylpropanoid namely podonaka A (1), along with the 13 known compounds including diterpenes (2 and 3), norditerpenes (4 and 5), benzenoids (6-10), steroids (11 and 12), chalcone (13), and megastigmane (14), was isolated from the EtOH extract of Podocarpus nakaii Hayata. The structure of 1 was elucidated on the basis of spectroscopic analysis including 1D and 2D NMR and MS techniques. Biological evaluation showed that norditerpenes, inumakilactone B (4), and podolactone E (5) have potent cytotoxic activities against Daoy, WiDr, KB, and HeLa tumor cell lines. Moreover, low dosage of 5 may induce early apoptosis in KB cells before 12 h.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Diterpenes / chemistry
-
Diterpenes / isolation & purification*
-
Diterpenes / pharmacology*
-
Drug Screening Assays, Antitumor
-
HeLa Cells
-
Humans
-
KB Cells
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Phenylpropionates / chemistry
-
Phenylpropionates / isolation & purification*
-
Phenylpropionates / pharmacology*
-
Plant Bark / chemistry
-
Plant Stems / chemistry
-
Plants, Medicinal / chemistry*
-
Taiwan
-
Tracheophyta / chemistry*
Substances
-
Antineoplastic Agents, Phytogenic
-
Diterpenes
-
Phenylpropionates
-
podonaka A