We theoretically investigate the quantum-path interference during the high harmonic generation in argon and observe the multi-quantum- path-interference (MQPI) effect related to the chirp of driving laser pulse. We successfully identify the interference originated from four significantly contributing quantum paths in the interaction of "isolated" atom with the driving laser field. Moreover, the MQPI effect is further demonstrated beyond the single atom response by spatial filtering which is used for angle-selective detection of transmitted light when three-dimensional propagation is considered. It implies that the role of high-order electron returning trajectories during high harmonic generation can be observed in the experiment.