The effect of maternal hemodynamics on fetal growth in hypertensive pregnancies

Am J Obstet Gynecol. 1991 Oct;165(4 Pt 1):902-6. doi: 10.1016/0002-9378(91)90436-u.

Abstract

Seventy-six pregnancies in which hypertension complicated pregnancy before 28 weeks' gestation were studied. In 36, hemodynamics were characterized by increased cardiac output and low vascular resistance; in 32, hemodynamics were characterized by high resistance; in eight hemodynamics crossed over from high output to high resistance during pregnancy. High-resistance hypertension was associated with a mean birth weight 1058 gm less than that in the low-resistance group (p = 0.001). The reduction in birth weight was due to a 4-week difference in gestational age (p = 0.001) and lower percentile weights for gestational age, 19th versus 39th (p = 0.005). Infants in the crossover group had low percentile weights and a high rate of intrauterine fetal death.

MeSH terms

  • Adult
  • Birth Weight
  • Cardiac Output / physiology*
  • Female
  • Fetal Growth Retardation / physiopathology*
  • Gestational Age
  • Hemodynamics / physiology
  • Humans
  • Hypertension / physiopathology*
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / physiopathology*
  • Vascular Resistance / physiology*