To be excluded or to bind, that is the question: Arginine effects on proteins

Makoto Nakakido; Motonori Kudou; Tsutomu Arakawa; Kouhei Tsumoto

doi:10.2174/138920109788488824

To be excluded or to bind, that is the question: Arginine effects on proteins

Curr Pharm Biotechnol. 2009 Jun;10(4):415-20. doi: 10.2174/138920109788488824.

Authors

Makoto Nakakido¹, Motonori Kudou, Tsutomu Arakawa, Kouhei Tsumoto

Affiliation

¹ Department of Medical Genome Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.

PMID: 19519417
DOI: 10.2174/138920109788488824

Abstract

In spite of its wide application to protein refolding, purification, and storage, we have not yet addressed a general solution to the mechanism of the effects of arginine hydrochloride on proteins. To elucidate the mechanism of the effects on proteins, several attempts have been reported. In this review, we would review the attempts from thermodynamic and kinetic viewpoints.

Publication types

Review

MeSH terms

Arginine / chemistry*
Binding Sites
Biopharmaceutics / methods*
Chemical Fractionation / methods
Multiprotein Complexes / chemistry*
Multiprotein Complexes / isolation & purification*
Protein Binding
Proteins / chemistry*
Proteins / isolation & purification*
Technology, Pharmaceutical / methods*

Substances

Multiprotein Complexes
Proteins
Arginine