Abstract
In 2007, a significant increase in acquired ampC genes in Enterobacteriaceae from 0.06% in 1999 to 1.3% was observed. Proteus mirabilis showed the highest prevalence (0.95%) and CMY-2 was the most prevalent AmpC enzyme (66.7%). Other enzymes such as CMY-4, DHA-1, ACC-1, and three new enzymes called CMY-25, CMY-27 and CMY-40 were detected. Seven out of the 117 isolates (6%) also produced an extended-spectrum beta-lactamase. As acquired AmpC enzymes are likely to become a serious public health issue worldwide, close surveillance is necessary to curb their spread.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution
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Bacterial Proteins / genetics*
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Drug Resistance, Bacterial
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Enterobacteriaceae / drug effects
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Enterobacteriaceae / enzymology
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Enterobacteriaceae / genetics*
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Enterobacteriaceae / isolation & purification
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Enterobacteriaceae Infections / epidemiology*
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Enterobacteriaceae Infections / microbiology*
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Hospitals
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Humans
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Molecular Sequence Data
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Plasmids / genetics
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Polymerase Chain Reaction
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Prevalence
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Spain / epidemiology
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beta-Lactamases / genetics*
Substances
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Bacterial Proteins
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AmpC beta-lactamases
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beta-Lactamases
Associated data
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GENBANK/EU515249
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GENBANK/EU515250
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GENBANK/EU515251