Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007

Clin Microbiol Infect. 2010 May;16(5):472-6. doi: 10.1111/j.1469-0691.2009.02864.x. Epub 2009 Jun 11.

Abstract

In 2007, a significant increase in acquired ampC genes in Enterobacteriaceae from 0.06% in 1999 to 1.3% was observed. Proteus mirabilis showed the highest prevalence (0.95%) and CMY-2 was the most prevalent AmpC enzyme (66.7%). Other enzymes such as CMY-4, DHA-1, ACC-1, and three new enzymes called CMY-25, CMY-27 and CMY-40 were detected. Seven out of the 117 isolates (6%) also produced an extended-spectrum beta-lactamase. As acquired AmpC enzymes are likely to become a serious public health issue worldwide, close surveillance is necessary to curb their spread.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Bacterial Proteins / genetics*
  • Drug Resistance, Bacterial
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / enzymology
  • Enterobacteriaceae / genetics*
  • Enterobacteriaceae / isolation & purification
  • Enterobacteriaceae Infections / epidemiology*
  • Enterobacteriaceae Infections / microbiology*
  • Hospitals
  • Humans
  • Molecular Sequence Data
  • Plasmids / genetics
  • Polymerase Chain Reaction
  • Prevalence
  • Spain / epidemiology
  • beta-Lactamases / genetics*

Substances

  • Bacterial Proteins
  • AmpC beta-lactamases
  • beta-Lactamases

Associated data

  • GENBANK/EU515249
  • GENBANK/EU515250
  • GENBANK/EU515251