Jagged gives endothelial tip cells an edge

Cell. 2009 Jun 12;137(6):988-90. doi: 10.1016/j.cell.2009.05.024.

Abstract

Sprouting blood vessels have tip cells that lead and stalk cells that follow. Benedito et al. (2009) now show that competition between endothelial cells for the tip position is regulated by glycosylation of Notch receptors and by the opposing actions of the Notch ligands Jagged1 and Delta-like 4.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Blood Vessels / cytology
  • Blood Vessels / embryology*
  • Calcium-Binding Proteins / metabolism*
  • Endothelial Cells / metabolism*
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Jagged-1 Protein
  • Membrane Proteins / metabolism*
  • Mice
  • Neovascularization, Physiologic*
  • Receptors, Notch / metabolism
  • Serrate-Jagged Proteins
  • Signal Transduction

Substances

  • Adaptor Proteins, Signal Transducing
  • Calcium-Binding Proteins
  • DLL4 protein, mouse
  • Intercellular Signaling Peptides and Proteins
  • Intracellular Signaling Peptides and Proteins
  • Jag1 protein, mouse
  • Jagged-1 Protein
  • Membrane Proteins
  • Receptors, Notch
  • Serrate-Jagged Proteins